Protein Folding Diseases Initiative


The Protein Folding Diseases (PFD) Initiative connects diverse campus-wide expertise on disorders of abnormal protein accumulation and perturbations in “protein quality control.”

This growing list of diseases numbers more than a hundred, with diseases affecting nearly all organ systems and ranging from some of the most common acquired disorders to a wide array of hereditary diseases.

Many PFD disorders are poorly understood, untreatable and often fatal. Accordingly, the unmet needs are tremendous. As one example, more than 5 million people in the U.S. now suffer from Alzheimer’s disease and, as our population ages, this number will climb rapidly

Similarly, for cancer treatment, the regulation of protein degradation has emerged as an important target with profound therapeutic implications

A better understanding of disease mechanisms and more effective therapies is needed for nearly all PFD disorders. The programs developed by the PFD Initiative promise to accelerate the path to new mechanistic insights and improved treatments for these diseases.


Welcome Dr. Ling Qi!

PFD's Newest Member and Faculty Recruit from Cornell University

Read more about Ling

Ling Qi








Juan Botas, Ph.D.

Thursday, May 11, 2017

PFDI Seminar Series

Juan Botas, Ph.D.,"Functional Dissection of Huntington's Disease Networks: from Association to Causal Modulators of Neurodegeneration"

Forum Hall, 1:00 PM