Central Biorepository Spotlight: U-M Pregnancy Biobank

Biorepository for Understanding Maternal and Pediatric Health

The University of Michigan Biorepository for Understanding Maternal and Pediatric Health (BUMP) is an active study of the Central Biorepository (CBR), a unit of the UMMS Office of Research, that facilitates discovery and improves healthcare outcomes by providing high-quality, highly annotated biospecimens donated for basic, clinical and translational research.

The unit receives biospecimens and data from U-M contributors and collaborators across a spectrum of medical research. These samples are annotated with clinical and research data and are accessible to members of the U-M research enterprise.

Types of Biospecimens

• First and Second Trimesters:
  • Maternal blood - plasma, PAXGene DNA, PAXGene RNA
  • Maternal urine
     
• Labor and Delivery:
  • Maternal blood - plasma, PAXGene DNA, PAXGene RNA
  • Maternal urine
  • Cord blood - plasma, PAXGene DNA, PAXGene RNA
  • Placenta - paraffin-embedded with H&E slides

Population

600+ total participants and counting! Currently enrolling pregnant women receiving obstetric care at Michigan Medicine Von Voightlander Women's Hospital.

Clinical data also available through secure links to Electronic Health Records (EHR).

Access

The Central Biorepository enables access to hundreds of available Biorepository for Understanding Maternal and Pediatric Health (BUMP) specimens from Michigan Medicine patients and offers secure linkage to laboratory and clinical data offered by the Data Office. 

Get started:

• Search the Obstetrics and Gynecology cohort on the self-serve tool, DataDirect.
• Complete and submit a CBR Use Proposal Form available on research.medicine.umich.edu/biorepository and send to CBR.requests@umich.edu.
• With IRB and oversight committee approval, datasets can be downloaded

"My patients are often surprised by how little we understand about the science of pregnancy, birth, and fetal development. The Michigan Medicine OB Biorepository is an amazing resource that provides the biological samples and medical data that we can use to become leaders in the science of supporting mothers and newborns.sed by how little we understand about the science of pregnancy, birth, and fetal development. The Michigan Medicine OB Biorepository is an amazing resource that provides the biological samples and medical data that we can use to become leaders in the science of supporting mothers and newborns."- Elizabeth Langen, M.D., Clinical Associate Professor, Obstetrics and Gynecology

The University of Michigan Biorepository for Understanding Maternal and Pediatric Health (BUMP)

The BUMP study aims to store biological samples obtained from human pregnancies and to provide a mechanism to link these specimens to health information for research projects. Potential research projects include those that are currently operating through other enrollment and collection mechanisms, as well as future work that is not yet planned. The team takes advantage of the large clinical volume of normal and complex pregnancies to obtain samples from varying points in pregnancy and the immediate postpartum period. The biorepository will provide a mechanism to link the biospecimens with health information so that it can later be shared with researchers to help advance maternal, fetal, and pediatric medicine.

View the full study sheet