Central Biorepository Spotlight: Organ Transplants

Immune Precision in Solid Organ Transplantation (ImPrec)

The Immune Precision in Solid Organ Transplantation (ImPrec) has an active study in the Central Biorepository, a unit of the UMMS Office of Research that facilitates discovery and improves healthcare outcomes by providing high-quality, highly annotated biospecimens donated for basic, clinical and translational research.

The unit receives biospecimens and data from U-M contributors and collaborators across a spectrum of medical research. Samples from Michigan Medicine patients are securely linked to MiChart data through the Research Data Warehouse

Types of Biospecimens

• Blood
• Cultured primary cells
• DNA
• Plasma
• Peripheral blood mononucleocytes
• Urine, supernatant and pellet
• RNA PAXgene tubes

Population

Currently enrolling new solid organ transplant recipients at U-M, in addition to already transplanted patients for specific case-controlled studies.

Clinical data also available through secure links to Electronic Health Records (EHR).

Access

The Central Biorepository enables access to Immune Precision in Solid Organ Transplantation (ImPrec) from Michigan Medicine patients and offers secure linkage to laboratory and clinical data offered by the Data Office.

Get started:

• Search the Solid Organ Transplantation cohort on the self-serve tool, DataDirect.
• Complete and submit a CBR Use Proposal Form available on research.medicine.umich.edu/biorepository and send to CBR.requests@umich.edu.
• With IRB and oversight committee approval, datasets can be downloaded

"While daunting to many, the ImPrec team fully embraces patient differences all the way down to the single-cell level. This unique approach is enabled for large cohorts by CBR and will reveal unprecedented rich molecular and cellular information to accelerate biomedical innovation for improved patient care." - Fei Wen, Ph.D., Associate Professor of Chemical Engineering

Immune Precision in Solid Organ Transplantation (ImPrec)

The goal of ImPrec is to identify novel risk stratifying instruments so that we can personalize immune suppression for solid organ transplant recipients. Currently, we use a “one size fits all” approach for immune suppression for recipients of solid organ transplants, which leads to over immune suppression (with increased risk of cancer and infections) or under immune suppression, with the increased risk of organ rejection. (Immune suppression is required to prevent rejection of transplanted organs). Identification of novel risk stratifiers will minimize the risk of generalized immune suppression and increase the efficacy of solid organ transplantation.

Learn more: Contact Sherri Wood at sychan@umich.edu or (734) 936-1173

View the full study sheet