Addressing an increasing trend of reports of failure to replicate important basic/preclinical studies, the NIH has introduced new standards for grant applications that require researchers consider the robustness of their proposed research, including:
- Scientific premise, or the research that forms the basis of proposed questions (i.e., consider the strengths and weaknesses of prior research and/or preliminary data),
- Scientific rigor, or the strict application of the scientific method to ensure robust and unbiased experimental design and results,
- Biological variables, such as sex, age, weight and underlying health conditions, and
- Key biological and/or chemical resources, such as cell lines, antibodies, specialty chemicals, etc.
The following resources provide context for these changes, as well as information about how to address them in your proposal sections, and we invite you to DOWNLOAD the "Understanding Rigor & Reproducibility Standards" presentation by Jill Jividen, Ph.D., Manager of Research Development.
- “Bolstering Trust in Science through Rigorous Standards”
- “Consideration of Relevant Biological Variables”
- “Scientific Premise in NIH Grant Applications”
- “Scientific Rigor in NIH Grant Applications”
Authentication of Key Biological and/or Chemical Resources
"Extramural Nexus: “What Kind of Information Should I Include…?”
"Open Mike: “Authentication of Key Biological and/or Chemical Resources in NIH Grant Applications”